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  • Title: Binding differences between nicotine and alpha-bungarotoxin in the rat brain.
    Author: Nukina I, Ogawa N, Takayama H, Ota Z.
    Journal: Res Commun Chem Pathol Pharmacol; 1985 Jan; 47(1):141-4. PubMed ID: 2858912.
    Abstract:
    Radioreceptor assay (RAA) results in rat brain with 3H-nicotine were compared with those obtained using 125I-alpha-Bungarotoxin (BTX). Scatchard analysis showed that the 3H-nicotine binding site had an average Kd and Bmax of 5.31 nM and 0.047 p moles/mg protein, respectively, and that the corresponding 125I-alpha-BTX binding site values were 0.092 nM and 0.044 p moles/mg protein. Cotinine, which is a nicotine metabolite and has a nicotine-like effect in vivo, inhibited 3H-nicotine binding but did not inhibit 125I-alpha-BTX binding. This result suggests that 3H-nicotine is a more useful ligand than 125I-alpha-BTX for investigating the pharmacological action of nicotine in the brain.
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