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  • Title: [Analysis on sero-epidemiological characteristics of hepatitis B virus among people born during 1994-2001 before and after hepatitis B vaccine catch-up vaccination, China].
    Author: Wang FZ, Zheng H, Miao N, Sun XJ, Zhang GM, Liang XF, Cui FQ.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2017 Jun 06; 51(6):469-474. PubMed ID: 28592087.
    Abstract:
    Objective: To analyze the sero-epidemiological characteristics of hepatitis B virus among people born during 1994-2001, conducted by the national hepatitis B sero-epidemiological surveys in 2006 and 2014. Methods: Based on the data of the two national hepatitis B sero-epidemiological surveys in 2006 and 2014, people born during 1994-2001 were included into our analysis as this study subjects. The two surveys were conducted in 160 disease surveillance points of 31 provinces (not including Hong Kong, Macao and Taiwan) in China. Face-to-face interviews with the subject by door to door or on the investigation site were conducted by trained staff using standard questionnaires to obtain basic information including birth date, sex, ethnicity, resident place and so on. And then 5 ml venous blood was collected. Enzyme-linked immunosorbent assay (ELISA) reagents were used for HBsAg, anti-HBs and anti-HBc measurements and Abbott micro-particle enzyme immunoassay (MEIA) reagents was used to confirm test. We analyzed HBsAg, anti-HBs and anti-HBc positive rate by gender, ethnicity, urban/rural, eastern/central/western region, birth years and compared the distribution of serum epidemiological characteristics in 2006 and 2014. Results: 19 821 and 4 712 people born during 1994-2001 were involved in 2006 and 2014 national serosurveys of China, respectively. For the people born during 1994-2001, HBsAg positive rate were 2.02% (95% CI: 1.82%-2.21%) in 2014 and 1.95% (95% CI: 1.56%-2.35%) in 2006. Anti-HBc positive rate were 7.94% (95%CI: 7.17%-8.71%) in 2014 and higher than that in 2006 (6.49%, 95%CI: 6.15%-6.83%), especially for the female (8.31%, 95% CI: 7.20%-9.43%), urban (7.45%, 95% CI: 6.38%-8.52%), western region (11.25%, 95%CI: 9.79%-12.71%), minority people (16.02%, 95%CI: 13.47%-18.57%) in 2014 were higher than that of the female (6.29%, 95% CI: 5.81%-6.78%), urban (4.82%, 95% CI: 4.40%-5.24%), western region (7.97%, 95% CI: 7.31%-8.63%), minority people (11.88%, 95% CI: 10.66%-13.00%) in 2006 respectively. Anti-HBs positive rate were 57.80% (95%CI: 57.11%-58.48%) in 2014 and 59.13% (95%CI: 57.72%-60.53%) in 2006. Anti-HBs positive rate of rural (58.80%, 95% CI: 56.83%-60.78%),western region (58.50%, 95% CI: 56.23%-60.78%), minority people (57.20%, 95% CI: 53.76%-60.63%) in 2014 was higher than of rural (52.62%, 95% CI: 51.64%-53.61%),western region (51.73%, 95% CI: 50.54%-52.96%),minority people (41.14%, 95%CI: 39.28%-43.00%) in 2006. Conclusion: Anti-HBc positive rate among people born during 1994-2001 in 2014 survey showed a rising tendency than in 2006. The risk of HBV infection was existed. Hepatitis B vaccine catch-up in childhood was necessary. 目的： 分析2006和2014年两次全国乙型肝炎血清流行病学调查中1994—2011年出生人群的乙型肝炎血清流行病学特征。 方法： 数据来自于2006和2014年两次全国乙型肝炎血清流行病学调查，以数据库中记录的1994—2001年出生的人群为研究对象。两次调查均覆盖了中国31个省份（不包括中国香港、澳门和台湾数据）的160个疾病监测点，并均采用入户或集中调查的方式，对研究对象进行问卷调查。调查内容包括出生日期、性别、民族、地区等。问卷调查后，采集静脉血5 ml待检。采用ELISA法检测HBsAg、抗-HBc及抗-HBs，采用微粒子酶免疫法（MEIA）进行复核。通过调查人群HBsAg、抗-HBs、抗-HBc阳性率及其95%CI值比较不同性别、民族、城乡、地区间分布差异。 结果： 2006年共有效调查1994—2001年出生者19 821名，2014年共有效调查4 712名。2006和2014年该年龄段人群HBsAg阳性率分别为2.02%（95%CI：1.82%~2.21%）和1.95%（95%CI：1.56%~2.35%）。2014年该年龄人群抗-HBc阳性率（7.94%，95%CI：7.17%~8.71%）高于2006年（6.49%，95%CI：6.15%~6.83%），2014年女性（8.31%，95%CI：7.20%~9.43%）、城市（7.45%，95%CI：6.38%~8.52%）、西部（11.25%，95%CI：9.79%~12.71%）、少数民族（16.02%，95%CI：13.47%~18.57%）抗-HBc阳性率高于2006年女性（6.29%，95%CI：5.81%~6.78%）、城市（4.82%，95%CI：4.40%~5.24%）、西部（7.97%，95%CI：7.31~8.63%）、少数民族（11.88%，95%CI：10.66%~13.00%）。2006和2014年调查的该年龄段人群抗-HBs阳性率分别为57.80%（95%CI：57.11%~58.48%）和59.13%（95%CI：57.72%~60.53%），2014年农村（58.80%，95% CI：56.83%~60.78%）、西部（58.50%，95%CI：56.23%~60.78%）、少数民族（57.20%，95%CI：53.76%~60.63%）人群抗-HBs阳性率均高于2006年农村（52.62%，95% CI：51.64%~53.61%）、西部（51.73%，95% CI：50.54%~52.96%）、少数民族（41.14%，95%CI：39.28%~43.00%）人群。 结论： 1994—2001年出生人群2014年调查抗-HBc阳性率较2006年有升高趋势，HBV感染风险存在，儿童期开展乙型肝炎疫苗查漏补种是必要的。.
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