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Title: [A cross-sectional study of seroepidemiology of viral hepatitis among Uighurs in Shufu of Xinjiang].
Author: Zhang ZB, Xue ZX, Yang QY, Wang TM, Li YH, Ma CY, Song XL, Wang G, Luo DM, Sulayman M, Rayhangul A, Zhao CH, Wang YZ, Wang M.
Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2017 Jun 06; 51(6):484-489. PubMed ID: 28592090.
Abstract:
Objective: To explore the status of seroepidemiology on hepatitis A, B and C among students and residents aged equal or greater than 18 years in south Xinjiang, and to provide scientific evidence for prevention and control of viral hepatitis. Methods: Uyghur students in four towns and villages were selected by cluster random sampling from Feb to May, 2015, and Uyghur residents aged 18 to 69 years were selected by stratified cluster sampling from May to September, 2016. 4 507 middle and primary Uygur students and 4 833 Uyghur resides equal or greater than 18 years attended this survey. Self-designed questionnaire was used to collect the demographic information. And Elisa test was adopted to detect HAV-IgG, HBsAg, HBsAb and HCV-IgG. Chi-square test was used to calculate the difference on antibody positive rate of three types of hepatitis among the participants. Results: The overall HAV-IgG positive rate was 99.45% (9 289/9 340). The positive rates were 99.70% (4 006/4 018) in male and 99.27% (5 283/5 322) in female (χ(2)=7.95, P=0.005). The HAV-IgG positive rate among people aged 10 to 14 years was the highest (99.91%, 2 233/2 235), and the difference between the age specific HAV-IgG positive rates was statistical significant (χ(2)=38.21, P<0.001). The overall HBsAg positive rate was 4.11% (384 cases), with 4.55% (183 cases) for male and 3.78% (201 cases) for female. The HBsAg positive rate among participants 19 to 24 years old was the highest (9.46%, 21/222) and the differences between the age specific HBsAg was statistically significant (χ(2)=116.22, P<0.001). The HBsAb positive rate was 35.03% (3 272 cases), with 35.59% (1 430 cases) for male and 34.61% (1 842 cases) for female, and the HBsAb positive rate among participants aged 15 to 18 years was the highest, which was 69.12% (696/1 007). The differences between the age specific HBsAb rates appeared statistically significant (χ(2)=671.80, P<0.001). The overall HCV-IgG positive rate was 0.65%(61 cases). The HCV-IgG positive rate in female was 0.86% (46 cases) and 0.37% (15 cases) in male (χ(2)=8.51, P=0.004).The HCV-IgG positive rate among participants aged over 70 years was the highest (3.78%,9/238) , and the difference between the age specific HCV-IgG positive rates had statistic significance (χ(2)=70.30, P<0.001). The HAV-IgG positive rate in hepatitis A vaccinees (100%, 876/876) was higher than that among the non-vaccinees (99.40%, 8 413/8 464) (χ(2)=4.26, P=0.039). The HBsAb positive rate in hepatitis B vaccinees was 39.32% (1 816/4 619) which was higher than that among the non-vaccinees (30.84%, 1 456/4 721) (χ(2)=73.68, P<0.001). Conclusion: The positive rate of overall HAV-IgG was high, male and participants aged between 10 to 14 had higher probability to be infected. But the infection rates of hepatitis B and C were low, with the low vaccination rate and the poor protective effectiveness of hepatitis B. 目的： 调查新疆疏附县维吾尔族人群中小学生及≥18岁者甲、乙、丙型病毒性肝炎流行情况。 方法： 于2015年2—5月，按照整群随机抽样的方法，在疏附县10个乡镇中抽取4个乡镇的中小学在校维吾尔族学生作为中小学生研究对象；并于2016年5—9月，采用分层整群抽样，利用随机数字表法在疏附县10个乡（镇）各抽取1个村，调查其间居住在村内18岁及以上维吾尔族居民全部纳入本次调查。共调查中小学维吾尔族学生4 507名，18岁及以上维吾尔族常住居民4 833名。采用自行设计问卷调查其人口学特征，采用Elisa检测抗-HAV IgG、HBsAg、HBsAb和丙型肝炎病毒IgG抗体（抗-HCV IgG）。采用χ(2)检验比较不同特征调查对象3种肝炎抗体阳性率差异。 结果： 9 340名调查对象抗-HAV IgG阳性率为99.45%（9 289例），其中男、女分别为99.70%（4 006/4 018），99.27%（5 283/5 322）（χ(2)=7.95，P=0.005）；10~14岁组抗-HAV IgG阳性率较高，为99.91%（2 233/2 235），≥70岁组较低，为98.32%（234/238），各年龄组差异有统计学意义（χ(2)=38.21，P<0.001）。HBsAg阳性率为4.11%（384例），其中男、女分别为4.55%（183例）、3.78%（201例）；19~24岁组HBsAg阳性率较高，为9.46%（21/222），5~9岁组较低，为0.87%（11/1 270），各年龄组差异有统计学意义（χ(2)=116.22，P<0.001）。HBsAb阳性率为35.03%（3 272例），男性为35.59%（1 430例），女性为34.61%（1 842例）；15~18岁组HBsAb阳性率较高，为69.12%(696/1 007)，5~9岁组较低，为21.18%（269/1 270），各年龄组HBsAb阳性率差异有统计学意义（χ(2)=671.80，P<0.001)。抗-HCV IgG阳性率为0.65%(61例)，其中男、女分别为0.37%（15例）、0.86%（46例）（χ(2)=8.51，P=0.004）；≥70岁组抗-HCV IgG阳性率最高，为3.78%（9/238），5~9岁组较低，为0.16%（2/1 270），各年龄组的抗-HCV IgG阳性率差异有统计学意义（χ(2)=70.30，P<0.001)。接种甲型肝炎疫苗者抗-HAV IgG的阳性率为100%（876/876），高于未接种者（99.40%，8 413/8 464）（χ(2)=4.26，P=0.039）；接种乙型肝炎疫苗者HBsAb的阳性率为39.32%（1 816/4 619），高于未接种疫苗者为（30.84%，1 456/4 721）（χ(2)=73.68，P<0.001）。 结论： 新疆疏附县维吾尔族人群甲型肝炎感染率高，男性及10~14岁人群感染甲型肝炎的高危人群，乙型肝炎和丙型肝炎感染率较低，但人群乙型肝炎疫苗保护效果差。.

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