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  • Title: Increased Interleukin-19 Expression in Cutaneous T-cell Lymphoma and Atopic Dermatitis.
    Author: Oka T, Sugaya M, Takahashi N, Nakajima R, Otobe S, Kabasawa M, Suga H, Miyagaki T, Asano Y, Sato S.
    Journal: Acta Derm Venereol; 2017 Nov 15; 97(10):1172-1177. PubMed ID: 28597022.
    Abstract:
    Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lym-phoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patients with AD and those with advanced-stage CTCL than in normal controls, correlating significantly with clinical disease markers. IL-19 mRNA levels in lesional skin of both diseases were significantly elevated. Immunohistochemical staining revealed that IL-19 was expressed in the epidermis of AD skin and CTCL skin. In vitro, IL-17A and IL-4 increased IL-19 mRNA expression in human keratinocytes. Thus, IL-19 was increased in the sera and skin of AD and CTCL. These results suggest that IL-19 is important for bridging Th17 to Th2 in these diseases.
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