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  • Title: [Role of dopamine receptors in the mechanism of action of neuroleptics].
    Author: Lavretskaia EF, Kats MM, Baldenkov GN.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1985; 85(3):431-5. PubMed ID: 2859724.
    Abstract:
    The authors analyze the literature and their own data on the influence of neuroleptics on the cerebral dopamine and adrenoreceptors. It is shown that antipsychotic activity of neuroleptics correlates with their ability to block D2 dopamine receptor whereas their sedative properties are in a better agreement with the blockade of alpha 1-adrenoreceptor. Effects at the molecular level, other than the blockade of the above receptors, may be involved in forming the activity spectrum of each drug.
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