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  • Title: Antibacterial constituents from Antarctic fungus, Aspergillus sydowii SP-1.
    Author: Li WT, Luo D, Huang JN, Wang LL, Zhang FG, Xi T, Liao JM, Lu YY.
    Journal: Nat Prod Res; 2018 Mar; 32(6):662-667. PubMed ID: 28602098.
    Abstract:
    One new alkaloid, named as acremolin C (1), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo-(L-Trp-L-Phe) (2), 4-hydroxyphenylacetic acid (3), (7S)-(+)-hydroxysydonic acid (4) and (7S, 11S)-(+)-12-hydroxysydonic acid (5), were isolated and identified. Biological studies disclosed that compounds 2, 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE.
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