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  • Title: Association of Adverse Events With Antibiotic Use in Hospitalized Patients.
    Author: Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE.
    Journal: JAMA Intern Med; 2017 Sep 01; 177(9):1308-1315. PubMed ID: 28604925.
    Abstract:
    IMPORTANCE: Estimates of the incidence of overall antibiotic-associated adverse drug events (ADEs) in hospitalized patients are generally unavailable. OBJECTIVE: To describe the incidence of antibiotic-associated ADEs for adult inpatients receiving systemic antibiotic therapy. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort of adult inpatients admitted to general medicine wards at an academic medical center. EXPOSURES: At least 24 hours of any parenteral or oral antibiotic therapy. MAIN OUTCOMES AND MEASURES: Medical records of 1488 patients were examined for 30 days after antibiotic initiation for the development of the following antibiotic-associated ADEs: gastrointestinal, dermatologic, musculoskeletal, hematologic, hepatobiliary, renal, cardiac, and neurologic; and 90 days for the development of Clostridium difficile infection or incident multidrug-resistant organism infection, based on adjudication by 2 infectious diseases trained clinicians. RESULTS: In 1488 patients, the median age was 59 years (interquartile range, 49-69 years), and 758 (51%) participants were female. A total of 298 (20%) patients experienced at least 1 antibiotic-associated ADE. Furthermore, 56 (20%) non-clinically indicated antibiotic regimens were associated with an ADE, including 7 cases of C difficile infection. Every additional 10 days of antibiotic therapy conferred a 3% increased risk of an ADE. The most common ADEs were gastrointestinal, renal, and hematologic abnormalities, accounting for 78 (42%), 45 (24%), and 28 (15%) 30-day ADEs, respectively. Notable differences were identified between the incidence of ADEs associated with specific antibiotics. CONCLUSIONS AND RELEVANCE: Although antibiotics may play a critical role when used appropriately, our findings underscore the importance of judicious antibiotic prescribing to reduce the harm that can result from antibiotic-associated ADEs.
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