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  • Title: Chronic pain in the rat: selective alterations in CNS and pituitary pools of dynorphin as compared to vasopressin.
    Author: Millan MJ, Millan MH, Pilcher CW, Colpaert FC, Herz A.
    Journal: Neuropeptides; 1985 Feb; 5(4-6):423-4. PubMed ID: 2860600.
    Abstract:
    Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin (VP) was not affected in these tissues but increased in midbrain. These effects might reflect a role of DYN in the control of chronic pain. In addition, they support a differential modulation of DYN as compared to VP extrinsic to the hypothalamic-neurohypophyseal axis.
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