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  • Title: Comparative actions of GABA and acetylcholine on the Xenopus laevis lateral line.
    Author: Bobbin RP, Bledsoe SC, Winbery S, Ceasar G, Jenison GL.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1985; 80(2):313-8. PubMed ID: 2861015.
    Abstract:
    The effects of GABA, acetylcholine and carbachol on the spontaneous activity of afferent nerve fibers in the lateral line of Xenopus laevis are characterized. Atropine and bicuculline were also tested on drug- and water motion-evoked activity. GABA (0.019-1.25 mM) suppressed and both acetylcholine (1.25-80 microM) and carbachol (1.25-40 microM) increased spontaneous activity. These actions were blocked by bicuculline (100 microM) and atropine (4 microM) respectively. Atropine (20 microM) and bicuculline (100 microM) had no effect on water motion-evoked activity. The results characterize actions of GABA and acetylcholine not previously described and provide evidence that does not support the hypothesis that GABA or acetylcholine are the afferent transmitter.
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