These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Phase-locked and non-phase-locked EEG responses to pinprick stimulation before and after experimentally-induced secondary hyperalgesia.
    Author: van den Broeke EN, de Vries B, Lambert J, Torta DM, Mouraux A.
    Journal: Clin Neurophysiol; 2017 Aug; 128(8):1445-1456. PubMed ID: 28618295.
    Abstract:
    OBJECTIVE: Pinprick-evoked brain potentials (PEPs) have been proposed as a technique to investigate secondary hyperalgesia and central sensitization in humans. However, the signal-to-noise (SNR) of PEPs is low. Here, using time-frequency analysis, we characterize the phase-locked and non-phase-locked EEG responses to pinprick stimulation, before and after secondary hyperalgesia. METHODS: Secondary hyperalgesia was induced using high-frequency electrical stimulation (HFS) of the left/right forearm skin in 16 volunteers. EEG responses to 64 and 96mN pinprick stimuli were elicited from both arms, before and 20min after HFS. RESULTS: Pinprick stimulation applied to normal skin elicited a phase-locked low-frequency (<5Hz) response followed by a reduction of alpha-band oscillations (7-10Hz). The low-frequency response was significantly increased when pinprick stimuli were delivered to the area of secondary hyperalgesia. There was no change in the reduction of alpha-band oscillations. Whereas the low-frequency response was enhanced for both 64 and 96mN intensities, PEPs analyzed in the time domain were only significantly enhanced for the 64mN intensity. CONCLUSIONS: Time-frequency analysis may be more sensitive than conventional time-domain analysis in revealing EEG changes associated to secondary hyperalgesia. SIGNIFICANCE: Time-frequency analysis of PEPs can be used to investigate central sensitization in humans.
    [Abstract] [Full Text] [Related] [New Search]