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  • Title: Effect of potent antiglucocorticoids on dexamethasone induced enzymes in cultured hepatoma and rat liver cells.
    Author: Santana MA, Chasserot-Bolaz S, Beck B, Pogson CI.
    Journal: Cancer Lett; 1985 Jul; 27(3):329-37. PubMed ID: 2861890.
    Abstract:
    The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation to time of culture; (ii) the extent of the inhibitory effect on enzyme induction depends on the nature of the antagonist; (iii) hepatoma cells, especially HTC cells, appeared more sensitive to glucocorticoid antagonism than liver cells.
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