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  • Title: Biochemical and physiological effects of S-32-468, a beta-adrenoceptor antagonist with possible oculoselectivity.
    Author: Nathanson JA.
    Journal: Curr Eye Res; 1985 Mar; 4(3):191-7. PubMed ID: 2861973.
    Abstract:
    S-32-468, a recently synthesized aryloxymethyl beta-adrenoceptor antagonist, was tested for its ability to inhibit activation of isoproterenol-stimulated adenylate cyclase activity in rabbit and human ciliary process, heart and lung. In both species, S-32-468 was a potent inhibitor of ocular beta-adrenoceptors, with a 9-12 fold selectivity over inhibition of beta-adrenoceptors in cardiac tissue. When applied topically, S-32-468 was more effective than timolol in decreasing intraocular pressure in normal albino rabbits.
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