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  • Title: Anti-diabetic xanthones from the bark of Garcinia xanthochymus.
    Author: Nguyen CN, Trinh BTD, Tran TB, Nguyen LT, Jäger AK, Nguyen LD.
    Journal: Bioorg Med Chem Lett; 2017 Aug 01; 27(15):3301-3304. PubMed ID: 28624142.
    Abstract:
    An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of 0.3±0.1μg/mL and 2.3±0.4μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3-12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC50 value of 4.1±0.3μM (compared with acarbose, IC50=900.0±3.0μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC50 value of 8.0±0.6μM (compared with RK682, IC50=4.4±0.3μM).
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