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  • Title: Effects of chronic beta-adrenergic blockade on hemodynamic and metabolic responses to endurance training.
    Author: Lawlor MR, Thomas DP, Michele JJ, Carey RA, Paolone AM, Bove AA.
    Journal: Med Sci Sports Exerc; 1985 Jun; 17(3):393-400. PubMed ID: 2862564.
    Abstract:
    To study the influence of chronic propranolol therapy on hemodynamic and metabolic adaptations associated with endurance training, five dogs given 250 mg X d-1 propranolol therapy (P) and five control dogs (NP) were endurance trained for 7 wk using a continuously increasing treadmill workload. The P group was also evaluated pre- and post-training off the drug (P-OD) to separate drug and training effects. Training lowered mean heart rate score (HR) to a standardized multistage dog treadmill test in the NP and P-OD (P less than 0.05) and had no effect on the HR of the P group while on propranolol. At a fixed submaximal workload there were also slight reductions in cardiac output in the P group which were more pronounced (P less than 0.10) following training, and a corresponding increase in a-vDO2. Pre- and post-training metabolic studies were performed at rest, during a fixed submaximal workload, and following 30 min of recovery. During exercise, blood glucose levels were significantly lower in the P group both before and after training. While NP showed no significant change in high-density lipoprotein bound cholesterol after training, the P-OD group demonstrated a significant fall in high-density lipoprotein bound cholesterol after training (P less than 0.05). These data indicate that endurance exercise training done in the presence of chronic beta-adrenergic blockade produces training-induced hemodynamic adaptations to exercise, but beta-blockade inhibits the changes in serum lipids and lipoprotein fractions normally seen in response to an exercise conditioning program.
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