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  • Title: Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review.
    Author: Asaji M, Tobino K, Murakami K, Goto Y, Sueyasu T, Nishizawa S, Yoshimine K, Munechika M, Ko Y, Yoshimatsu Y, Tsuruno K, Ide H, Miyajima H, Ebi N.
    Journal: Intern Med; 2017; 56(12):1591-1596. PubMed ID: 28626190.
    Abstract:
    We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis. Therefore, a diagnosis of miliary tuberculosis-associated HPS was made. The patient was successfully treated with antituberculous therapy.
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