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  • Title: Evaluation of Continuous Negative External Pressure (cNEP) for the Treatment of Obstructive Sleep Apnea: A Pilot Study.
    Author: Kram JA, Woidtke RV, Klein KB, Rose RM.
    Journal: J Clin Sleep Med; 2017 Aug 15; 13(8):1009-1012. PubMed ID: 28633720.
    Abstract:
    STUDY OBJECTIVES: To determine if the application of continuous negative external pressure (cNEP) is effective and safe in individuals with obstructive sleep apnea (OSA) during an overnight in-laboratory sleep study. METHODS: A prospective, open-label pilot study in subjects with documented OSA recruited from the patient population at one sleep clinic. The intervention was application and titration of cNEP during overnight polysomnography. RESULTS: Of the 15 subjects studied (mean apnea-hypopnea index [AHI] at baseline, 43.9 events/h), 13 (87%) were responders to cNEP: 9 had an excellent response (AHI < 5 events/h) and 4 had a partial response (AHI < 50% baseline and < 15 events/h). Three minor, self-limited adverse events occurred, which appeared related to contact pressure of the cNEP device on the skin. CONCLUSIONS: In this pilot study, cNEP appears to be safe and effective during short-term use in subjects with OSA. Further studies are warranted.
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