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  • Title: Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors.
    Author: Zhang L, Bu T, Bao X, Liang T, Ge Y, Xu Y, Zhu Q.
    Journal: Bioorg Med Chem Lett; 2017 Aug 01; 27(15):3395-3398. PubMed ID: 28633896.
    Abstract:
    A series of 3H-imidazo [4,5-b] pyridines derivatives were designed and synthesized as selective mTOR inhibitors. The systematic optimization of the molecules resulted in the identification of two compounds 10d and 10n with nanomolar mTOR inhibitory activity and selectivity over PI3Kα. Besides, compounds 10d and 10n demonstrated attractive potency against human breast cancer cells (MCF-7) and human ovarian cancer cell (A2780).
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