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  • Title: Somatostatin and peripheral blood flow in man.
    Author: Savi L, Cardillo C, Bombardieri G.
    Journal: Angiology; 1985 Aug; 36(8):511-5. PubMed ID: 2864003.
    Abstract:
    Somatostatin (SS), a physiological substance which inhibits secretion of GH, TSH, glucagon and insulin, was evaluated as a vasoactive agent. In normal and arteriopathic subjects SS was administered intravenously by bolus for 3 minutes and by infusion for 30 minutes. Rheography and plethysmography of lower limbs were performed before, during and after somatostatin administration. A marked improvement of blood flow, provoked by somatostatin, was observed. A reduction of heart rate was also observed. Some hypotheses about the mechanism with which SS acts upon peripheral circulation are discussed.
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