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  • Title: Effects of insulin on net hepatic metabolism of acetate and beta-hydroxybutyrate in sheep (Ovis aries).
    Author: Brockman RP, Laarveld B.
    Journal: Comp Biochem Physiol A Comp Physiol; 1985; 81(2):255-7. PubMed ID: 2864166.
    Abstract:
    The net productions of acetate and beta-hydroxybutyrate by the liver and portal-drained viscera were determined before and during insulin plus glucose infusions. Glucose was infused at rates to maintain euglycemia. During insulin infusion the net hepatic productions of beta-hydroxybutyrate and acetate were reduced to a greater extent than could be accounted for by a reduction in provision of free fatty acids to the liver. It is concluded that insulin has a direct anti-ketogenic effect on the ovine liver.
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