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  • Title: The effect of different types of cortical lesions on drug-induced catalepsy in rats: a pharmacological analysis.
    Author: Worms P, Willigens MT, Continsouza-Blanc D, Lloyd KG.
    Journal: Eur J Pharmacol; 1985 Jul 11; 113(1):53-9. PubMed ID: 2864264.
    Abstract:
    The effect of bilateral lesions of various cortical areas on neuroleptic- and non-neuroleptic-induced catalepsy was studied in the rat. Ablation of the frontal or parietal cortex led to a marked decrease in haloperidol catalepsy, whereas lesions of the occipital cortex, or of the olfactory bulbs did not affect catalepsy, when measured 3 weeks post lesion in all cases. The frontal cortex lesions also diminished the cataleptic state induced by cis-flupenthixol, (+)-butaclamol and chlorpromazine, but failed to affect that induced by reserpine, tetrabenazine or morphine. Four months after the frontal lesions, haloperidol catalepsy was at control values, and a rebound phenomenon was observed at 10 months post lesion. The homeostatic mechanisms seem to have stabilized at 18 months post lesion when haloperidol catalepsy had returned to control levels.
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