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  • Title: B cell activity and regulatory T cell function in systemic lupus erythematosus by human B cell colony formation.
    Author: Otsuka T, Okamura S, Niho Y, Kusaba T.
    Journal: J Rheumatol; 1985 Jun; 12(3):508-13. PubMed ID: 2864442.
    Abstract:
    We have examined the ability of B cells from patients with systemic lupus erythematosus (SLE) to form colonies in vitro. Significantly more B cell colonies growing in the absence of irradiated T cells were observed in patients with active SLE. Helper T cell function of active SLE was normal. Culture supernatants of SLE T cells had significantly less activity to support the B cell colony formation. Our results suggest that the hyperactivity of B cells in SLE may reside in the lupus B cells themselves and that SLE T cells are defective in releasing the soluble factor.
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