These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biotransformation of bile acids by clostridia.
    Author: Owen RW.
    Journal: J Med Microbiol; 1985 Oct; 20(2):233-8. PubMed ID: 2864454.
    Abstract:
    The metabolism of bile acids by nuclear dehydrogenating clostridia (NDC) was studied. NDC were able to desaturate the A-ring of 5 beta-cholan-3-oxo-24-oic acid, 12 alpha-hydroxy-5 beta-cholan-3-oxo-24-oic acid, 7 alpha-hydroxy-5 beta-cholan-3-oxo-24-oic acid, 6 alpha-hydroxy-5 beta-cholan-3-oxo-24-oic acid, 7 alpha, 12 alpha-dihydroxy-5 beta-cholan-3-oxo-24-oic acid, 3,12-dioxo-5 beta-cholan-24-oic acid but not 3,6-dioxo-5 beta-cholan-24-oic acid, 3,7-dioxo-5 beta-cholan-24-oic acid and 3,7,12-trioxo-5 beta-cholan-24-oic acid. In each case the sole product possessed a 4-ene-3-one structure. Desaturation of bile acids was more efficient than that of androstanes. NDC are, therefore, capable of introducing double bonds into the nucleus of bile acids as well as that of androstanes. The physiological significance of such reactions in relation to large bowel cancer has yet to be elucidated.
    [Abstract] [Full Text] [Related] [New Search]