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Title: [Prevalence of dyslipidemia and normal blood lipids level in Uygur population in Kashgar area of Xinjiang Uygur Autonomous Region].
Author: Zhang ZB, Xue ZX, Wu XJ, Wang TM, Li YH, Song XL, Chao XF, Wang G, Nazibam N, Ayxamgul B, Gulbahar E, Zhou ZY, Sun BS, Wang YZ, Wang M.
Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2017 Jun 10; 38(6):702-708. PubMed ID: 28647967.
Abstract:
Objective: To understand the prevalence of dyslipidemia and normal blood lipids level in Uygur diabetes patients in Kashgar prefecture in southern area of Xinjiang. Methods: A total of 5 078 local residents aged ≥18 years (42.56% were men) selected through cluster random sampling in Kashgar were surveyed by means of questionnaire survey, physical examination and laboratory test, and 521 diabetes patients were screened. Results: The overall prevalence of dyslipidemia in diabetes patients was 59.50% (310/521) with adjusted rate as 49.39%. Age ≥65 years, overweight, obesity and abdominal obesity increased the risk for dyslipidemia by 0.771 times (95% CI: 1.015-3.088), 1.132 times (95% CI: 1.290-3.523), 1.688 times (95% CI: 1.573-4.592) and 0.801 times (95% CI: 1.028-3.155) respectively. Compared with males, female was a protective factor for dyslipidemia (OR=0.507, 95%CI: 0.334-0.769). The overall normal rate of blood lipids level including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for type 2 diabetes patients was 11.13%. Female, higher BMI and abdominal obesity were the factors influencing the overall normal blood lipids level. The normal rate of LDL-C level decreased with increase of age, BMI and waist circumferences (trend test χ(2)=18.049, P<0.001; trend test χ(2)=10.582, P=0.001; χ(2)=19.081, P<0.001), but increased with educational level (trend test χ(2)=9.764, P=0.002). Conclusion: The prevalence of dyslipidemia in Uygur diabetes patients in Kashgar was high, however, the overall normal rate of blood lipid level was relatively low. Obesity was the most important risk factor for dyslipidemia in this area. More attention should be paid to dyslipidemia prevention in women. 目的： 了解新疆喀什地区维吾尔族糖尿病人群血脂异常及控制情况，为防治该地区糖尿病人群血脂紊乱提供依据。 方法： 采用分层整群随机抽样方法，对该地区5 078名18岁及以上的常住居民进行调查问卷、体格检查和实验室检测后，筛查糖尿病患者521例，描述其血脂异常以及各项血脂控制情况，分析造成血脂异常和影响血脂控制的因素。 结果： 糖尿病人群血脂代谢异常总患病率为59.50%（310/521），标化率为49.39%。65岁以上、超重、肥胖和腹部肥胖者发生血脂异常的风险分别增高0.771倍（95%CI：1.015~3.088）、1.132倍（95%CI：1.290~3.523）、1.688倍（95%CI：1.573~4.592）和0.801倍（95%CI：1.028~3.155）。和男性相比，女性是血脂异常的保护性因素，OR=0.507（95%CI：0.334~0.769）。TC、TG、HDL-C和LDL-C的总体控制率为11.13%。女性、BMI超标和腹部肥胖不利于血脂的总体控制。LDL-C的控制率随年龄、BMI和腰围的增大而降低（趋势检验χ(2)(年龄)=18.049，P<0.001；趋势检验χ(2)(BMI)=10.582，P=0.001；χ(2)(腰围)=19.081，P<0.001），随学历增高而增高（趋势检验χ(2)=9.764，P=0.002）。 结论： 该地区糖尿病人群血脂异常率处于较高水平，血脂总控制率则处于较低水平。肥胖是造成该地区糖尿病人群发生血脂异常的主要危险因素；女性在糖尿病血脂异常的防治中应该得到更多的重视。.

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