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Title: Dynorphin-A(1-8) and gamma-melanotropin exist within different myenteric plexus neurons of rat duodenum. Author: Wolter HJ. Journal: Biochem Biophys Res Commun; 1985 Sep 16; 131(2):821-6. PubMed ID: 2864926. Abstract: Using the adjacent serial section staining technique and the double staining elution method, it was demonstrated that the opioid peptide dynorphin-A(1-8), originating from the prodynorphin precursor, and gamma 3-melanotropin (gamma 3-MSH), originating from the pro-opiomelanocortin (POMC) precursor, did not co-exist within myenteric plexus perikarya of the rat duodenum. This finding resembles that of the rat brain. Whether gamma 3 -MSH and dynorphin-A(1-8) act synergistically or antagonize each other in some physiological functions or have no interaction at all in the rat duodenum is as yet unknown.[Abstract] [Full Text] [Related] [New Search]