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  • Title: Effect of nicardipine on left ventricular function and on angina induced by atrial pacing in patients with coronary artery disease.
    Author: Lipkin DP, Poole-Wilson PA.
    Journal: Int J Cardiol; 1985 Nov; 9(3):303-10. PubMed ID: 2865217.
    Abstract:
    The effect of intravenous nicardipine, a new calcium antagonist, on haemodynamics, left ventricular function and angina induced by atrial pacing has been investigated in patients with coronary artery disease. Patients were treated with beta-blockers and measurements were made at a fixed heart rate. Nicardipine produced a 24% fall in mean systemic blood pressure (P less than 0.02) and a 37% increase in cardiac index (P less than 0.02). Cardiac filling pressures, dp/dt max and left ventricular ejection fraction were unaltered. The time to pacing induced angina was prolonged (P less than 0.05) when the dose of nicardipine (0.75 mg X min-1) was selected not to cause an excessive fall in blood pressure. Nicardipine is a powerful arteriodilator without detectable negative inotropic effects and prolongs the time to pacing induced angina.
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