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  • Title: Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus.
    Author: Slater NT, Stelzer A, Galvan M.
    Journal: Neurosci Lett; 1985 Sep 16; 60(1):25-31. PubMed ID: 2865705.
    Abstract:
    In the guinea pig in vitro hippocampal slice preparation, we have demonstrated that the repeated tetanic stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurones produces a progressive increase in the amplitude and duration of postsynaptic potentials, and stimulus-induced and spontaneous paroxysmal depolarization shifts (PDSs). Both the enhancement of synaptic transmission and the genesis of PDSs were reversibly blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist (+/-)-2-amino-5-phosphonovalerate (APV). These results provide evidence that progressive, stimulation-induced long-term potentiation may serve as the trigger for kindling-induced epileptogenesis, and this process is dependent on the repeated activation of an APV-sensitive receptor.
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