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  • Title: Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol.
    Author: Alkondon M, Ray A, Sen P.
    Journal: Arch Int Pharmacodyn Ther; 1985 Sep; 277(1):161-7. PubMed ID: 2865935.
    Abstract:
    Propranolol in low doses antagonized and in higher doses facilitated oxotremorine-induced tremor (Oxo-tremor) in mice. Atropine blocked Oxo-tremor, an effect that was reversed by propranolol. Atropine pretreatment also antagonized the potentiating effect of propranolol on Oxo-tremor. Propranolol inhibited mice brain cholinesterase at doses which enhanced Oxo-tremor. Timolol and sotalol produced a dose-dependent antagonism of Oxo-tremor, whereas practolol failed to produce a similar effect. None of these three agents produced any significant enhancement of Oxo-tremor. These results suggest the involvement of a peripheral mechanism for the antagonism and a central cholinergic mechanism for the facilitation of Oxo-tremor by propranolol.
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