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  • Title: Effects of changes in dietary sodium intake and saline infusion on immunoreactive atrial natriuretic peptide in human plasma.
    Author: Sagnella GA, Markandu ND, Shore AC, MacGregor GA.
    Journal: Lancet; 1985 Nov 30; 2(8466):1208-11. PubMed ID: 2866291.
    Abstract:
    Plasma levels of immunoreactive atrial natriuretic peptide (IrANP) were measured in healthy normotensive subjects before and after saline infusion and changes in dietary salt intakes. When 2 litres of 0.9% saline (308 mmol Na+) were infused over 1 h, plasma levels (mean +/- SD) of IrANP increased from 5.8 +/- 2.8 pg/ml to 15.8 +/- 12.5 pg/ml. Plasma levels on the fifth day of a low sodium diet (10 mmol/day) were 3.8 +/- 2.4 pg/ml, a normal sodium intake (150 mmol/day) 6.4 +/- 2.9 pg/ml, and a high salt intake (350 mmol/day) 12.7 +/- 6 pg/ml. These results suggest that atrial natriuretic peptides could be important hormones in the control of sodium balance in normal man.
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