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Title: Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors. Author: Aramburu IV, Lemke EA. Journal: Semin Cell Dev Biol; 2017 Aug; 68():34-41. PubMed ID: 28669824. Abstract: The nuclear pore complex (NPC) forms a permeability barrier between the nucleus and the cytoplasm. Molecules that are able to cross this permeability barrier encounter different disordered phenylalanine glycine rich nucleoporins (FG-Nups) that act as a molecular filter and regulate the selective NPC crossing of biomolecules. In this review, we provide a current overview regarding the interaction mechanism between FG-Nups and the carrier molecules that recognize and enable the transport of cargoes through the NPC aiming to understand the general molecular mechanisms that facilitate the nucleocytoplasmic transport.[Abstract] [Full Text] [Related] [New Search]