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  • Title: Tricyclic antidepressant plasma level monitoring: an improvement over the dose-response approach.
    Author: Preskorn SH.
    Journal: J Clin Psychiatry; 1986 Jan; 47(1 Suppl):24-30. PubMed ID: 2867088.
    Abstract:
    Monitoring plasma levels of tricyclic antidepressants (TCAs) can facilitate treatment response by providing objective guidelines for dosage adjustment. It provides a means of assessing the patient's compliance and ensuring the maintenance of an adequate medication trial while avoiding the complications of drug toxicity. The traditional dose-response method of medication adjustment depends on several assumptions that are not met in the case of TCAs, which makes plasma monitoring particularly useful for patients receiving most TCAs.
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