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  • Title: Duodenal somatostatinoma with psammoma bodies: an immunohistochemical and ultrastructural study.
    Author: Taccagni GL, Carlucci M, Sironi M, Cantaboni A, Di Carlo V.
    Journal: Am J Gastroenterol; 1986 Jan; 81(1):33-7. PubMed ID: 2867674.
    Abstract:
    We report a case of malignant somatostatinoma of the ampulla of Vater in a 38-year-old woman with diabetes and cholelithiasis. Immunohistochemistry showed that tumor cells contained only somatostatin and electron microscopy revealed D-type granules in their cytoplasm. Psammoma bodies were numerous and appeared to originate in the cytoplasm of somatostatin producing cells. A review of the literature reveals that somatostatinomas with psammoma bodies are found only in the duodenum and do not produce significant amounts of peptides other than somatostatin.
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