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  • Title: Bicyclic compounds with potential antiulcer and/or antisecretory activity. I. 4,5,6,7-Tetrahydrobenzimidazoles.
    Author: Scarponi U, Cimaschi R, Rusconi L, Santangelo F, Arcari G, Castello R, Toti D, de Castiglione R.
    Journal: Farmaco Sci; 1985 Nov; 40(11):818-32. PubMed ID: 2867933.
    Abstract:
    The remarkable antiulcer and antisecretory activity of some previously described 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine derivatives prompted us to further investigate related bicyclic systems. Accordingly, a series of 5-amino- and 5-aminomethyl-4,5,6,7-tetrahydrobenzimidazoles, regiospecifically alkylated in position 1, were synthesized and tested. Only a few 1-ethyl-5-amino derivatives displayed a reasonable antiulcer activity in comparison with our former class of compounds.
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