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  • Title: A randomised controlled trial to investigate the remineralising potential of Tooth Mousse™ in orthodontic patients.
    Author: Garry AP, Flannigan NL, Cooper L, Komarov G, Burnside G, Higham SM.
    Journal: J Orthod; 2017 Sep; 44(3):147-156. PubMed ID: 28681698.
    Abstract:
    OBJECTIVE: To investigate the remineralisation of enamel subsurface lesions treated with fluoride toothpaste (1450 ppm) or a combination of fluoride toothpaste in addition to Tooth Mousse™. DESIGN: An in situ, cross-over, randomised controlled trial. SETTING: Orthodontic department at Liverpool University Dental Hospital, UK. PARTICIPANTS: Twelve patients receiving fixed orthodontic treatment. METHODS: Demineralised subsurface enamel lesions were placed in a carrier and attached onto a fixed orthodontic appliance. Interventions were either standard fluoride toothpaste or CPP-ACP paste (Tooth Mousse™) in addition to the fluoride toothpaste. Participants received both interventions in a randomised order. Transverse microradiography analysis was used to compare lesion mineral content profiles. RESULTS: Mineral loss was reduced by 15.4 and 24.6% between the fluoride and CPP-ACP groups, respectively (p = 0.023). Lesion depth was reduced by 1.6 and 11.1% between the fluoride and CPP-ACP groups, respectively (p = 0.037). Lesion width was reduced by 4.5 and 15.3% between the fluoride and CPP-ACP groups, respectively (p = 0.015). CONCLUSIONS: Remineralisation occurred regardless of treatment group allocation. However, the addition of Tooth Mousse™ resulted in a significantly increased remineralisation effect, compared to fluoride alone. Tooth Mousse™ may be beneficial for patients undergoing orthodontic treatment who are at high risk of demineralisation. TRIAL REGISTRATION: Registered on Current Control Trials http://www.controlled-trials.com/ISRCTN04899524.
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