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  • Title: Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA.
    Author: Kamal Masud M, Islam MN, Haque MH, Tanaka S, Gopalan V, Alici G, Nguyen NT, Lam AK, Hossain MSA, Yamauchi Y, Shiddiky MJA.
    Journal: Chem Commun (Camb); 2017 Jul 18; 53(58):8231-8234. PubMed ID: 28681881.
    Abstract:
    This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).
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