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  • Title: In vitro and in vivo assessment of newer quinoxaline-oxadiazole hybrids as antimicrobial and antiprotozoal agents.
    Author: Patel NB, Patel JN, Purohit AC, Patel VM, Rajani DP, Moo-Puc R, Lopez-Cedillo JC, Nogueda-Torres B, Rivera G.
    Journal: Int J Antimicrob Agents; 2017 Sep; 50(3):413-418. PubMed ID: 28687457.
    Abstract:
    A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a-o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.
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