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  • Title: Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy.
    Author: Liu CH, Wu WC, Sun MH, Kao LY, Lee YS, Chen HS.
    Journal: Invest Ophthalmol Vis Sci; 2017 Jul 01; 58(9):3350-3356. PubMed ID: 28687846.
    Abstract:
    PURPOSE: To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between nonarteritic anterior ischemic optic neuropathy (NAION) and open angle glaucoma (OAG) with altitudinal hemifield visual field defects. METHODS: This retrospective cross-sectional study included 10 NAION eyes and 16 OAG eyes, both demonstrating hemifield visual field defects, and 27 normal eyes serving as controls. The peripapillary and macular OCT-A scans were acquired. The retinal vessel density data were compared among NAION, glaucomatous, as well as control eyes. RESULTS: There was statistically significant difference in peripapillary whole image vessel density (wiVD), circumpapillary vessel density (cpVD), macular wiVD, and perifoveal vessel density (pfVD) between the three groups (P < 0.05 for all). In comparison between OAG and NAION groups, the NAION group demonstrated marked decrease in average cpVD (P = 0.008) and in most sectors of cpVD except the inferior one, while the OAG group demonstrated significant decreased macular wiVD and pfVD (P = 0.03 and 0.003, respectively). Multivariate analysis indicated that average thickness of retinal nerve fiber layer was the only predictor for peripapillary wiVD and cpVD (P = 0.005 for both). By contrast, thickness of ganglion cell complex was the only predictor for macular wiVD (P = 0.007). CONCLUSIONS: OCT-A detected significant difference in peripapillary and macular retinal vessel densities between OAG and NAION eyes. These differences might provide comparative insight into the pathophysiology of these two diseases.
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