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  • Title: Preparation, Structure, and Potent Antifouling Activity of Sclerotioramine Derivatives.
    Author: Wei MY, Wang CF, Wang KL, Qian PY, Wang CY, Shao CL.
    Journal: Mar Biotechnol (NY); 2017 Aug; 19(4):372-378. PubMed ID: 28688034.
    Abstract:
    A series of 30 sclerotioramine derivatives (2-31) of the natural compound, (+)-sclerotiorin (1), has been successfully semi-synthesized by a one-step reaction with high yields (up to 80%). The structures of these new derivatives were established by extensive spectroscopic methods and single-crystal X-ray diffraction analysis for 3, 6, and 10. (+)-Sclerotiorin (1) and its semisynthetic derivatives (2-31) were evaluated for their antifouling activity. Most of them except 6, 7, 8, 12, and 28 showed potent antifouling activity against the larval settlement of the barnacle Balanus amphitrite. More interestingly, most of the aromatic amino-derivatives (13-17, 19-21, 23, 25-27, and 29-31) showed strong antifouling activity; however, only two aliphatic amino-derivatives (5 and 10) had the activity.
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