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  • Title: Controlled trial on three beta-blockers: antihypertensive efficacy and effect on the hypertensive heart disease.
    Author: Pupita F, Ansuini R, Belogi M, Pupita G, Gaggi S.
    Journal: Int J Clin Pharmacol Res; 1985; 5(6):439-45. PubMed ID: 2869001.
    Abstract:
    Treatment of 66 hypertensive patients with three different beta-blockers (atenolol 100 mg once a day; oxprenolol 80 mg twice a day; nadolol 80 mg once a day) for six months resulted in a significant reduction in blood pressure and heart rate, the maximum with nadolol, a significant amelioration in pre-ejection period/left ventricular ejection time ratio expressing the haemodynamic performance of the left ventricle with atenolol and nadolol, and a significant reduction left ventricular hypertrophy as expressed by the Romhilt-Estes index with all three drugs, but especially with nadolol.
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