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  • Title: Evaluation of the need for prophylactic antiparkinsonian medication in psychotic patients treated with neuroleptics.
    Author: Manos N, Lavrentiadis G, Gkiouzepas J.
    Journal: J Clin Psychiatry; 1986 Mar; 47(3):114-6. PubMed ID: 2869027.
    Abstract:
    A double-blind study of 42 psychotic patients treated with neuroleptics evaluated the need for prophylactic use of antiparkinsonian medication. The patients assigned to placebo (N = 27) presented significantly more severe extrapyramidal symptomatology, particularly dystonias, than those given trihexyphenidyl (N = 15), indicating a need for the prophylactic use of antiparkinsonian medication during treatment with neuroleptics.
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