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  • Title: Alprazolam treatment of postcoronary bypass anxiety and depression.
    Author: Freeman AM, Fleece L, Folks DG, Sokol RS, Hall KR, Pacifico AD, McGiffin DC, Kirklin JK, Zorn GL, Karp RB.
    Journal: J Clin Psychopharmacol; 1986 Feb; 6(1):39-41. PubMed ID: 2869060.
    Abstract:
    The effectiveness of alprazolam in treating symptoms of anxiety and depression in 60 patients undergoing coronary bypass surgery was assessed in a double-blind, placebo-controlled study. The results indicate that alprazolam treatment for anxiety following coronary bypass surgery, particularly symptoms occurring in the immediate postoperative period, can significantly affect patient outcome. Specifically, only modest but statistically significant improvement was observed in the alprazolam-treated groups at 1-month follow-up; however, alprazolam-treated patients were significantly more likely to experience a very rapid anxiolytic effect by postoperative day 8. The implications of this study are discussed with respect to patient management and models for future studies of anxiety in postoperative patient populations.
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