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  • Title: The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia.
    Author: Cross AJ, Crow TJ, Ferrier IN, Johnson JA.
    Journal: Neurobiol Aging; 1986; 7(1):3-7. PubMed ID: 2869422.
    Abstract:
    The high-affinity binding of thirteen ligands to putative neurotransmitter receptors was studied in temporal cortex of control and Alzheimer-type dementia (ATD) patients. A selective reduction of serotonin S2 receptors was observed in the ATD patients, to 57% of controls with no change in S1 receptors. Of the other ligand binding sites studied, only 3H-flunitrazepam binding was significantly reduced, to 84% of controls. Ligand binding sites which were unchanged in ATD temporal cortex included those labelled by adrenergic, adenosine, histamine, opiate, GABA, benzodiazepine and cholinergic ligands.
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