These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Vasoactive intestinal polypeptide and somatostatin in experimental endogenous gram-negative peritonitis.
    Author: Almdahl SM, Jenssen TG, Burhol PG, Giercksky KE.
    Journal: Acta Chir Scand; 1986 Feb; 152():135-8. PubMed ID: 2869631.
    Abstract:
    Vasoactive intestinal polypeptide (VIP) and somatostatin were measured during endogenous gram-negative peritonitis and septicaemia in rats. Both peptides were found to increase in blood, but not in peritoneal fluid. The VIP values coincided with the levels of endotoxin and bacterial counts. However, if the development of profound shock was prevented by intravenous fluid supply, scarcely any changes in plasma VIP or somatostatin were found. Somatostatin is known to inhibit VIP. Our findings suggested breakdown of this regulatory inhibition in lethal gram-negative sepsis. They also supported the concept that specific release of the peptides takes place, not merely passive diffusion from injured cells.
    [Abstract] [Full Text] [Related] [New Search]