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  • Title: Antihypertensive effects of bisoprolol during once daily administration in patients with essential hypertension. A dose-ranging study with parallel groups.
    Author: Weiner L, Frithz G.
    Journal: Eur J Clin Pharmacol; 1986; 29(5):517-21. PubMed ID: 2869951.
    Abstract:
    Bisoprolol is a new beta 1-selective beta-blocking agent with a plasma half-time of 10-12 h and without partial agonist properties. Forty-eight patients with essential hypertension were randomly treated with 5, 10, or 20 mg bisoprolol given once daily for 8 weeks. All measurements were made 24 hours after the last dose. Bisoprolol had antihypertensive and beta-blocking properties both at rest and during exercise. The 20 mg dosage regimen was more effective than that of 5 mg and 10 mg. The drug was well tolerated and all the 48 patients completed the trial.
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