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  • Title: Ultrasonic absorption evidence of structural fluctuations in viral capsids.
    Author: Cerf R, Michels B, Schulz JA, Witz J, Pfeiffer P, Hirth L.
    Journal: Proc Natl Acad Sci U S A; 1979 Apr; 76(4):1780-2. PubMed ID: 287017.
    Abstract:
    When the coat protein of the small icosahedral virus, brome mosaic virus, reassembles into capsids, the ultrasonic absorption of the solution greatly increases. Submitting the solution to an ultrasonic field thus appears to reveal spontaneous molecular motions within a protein assembly. Confirmatory evidence of a dynamics of a protein shell comes from measurements on brome mosaic virus at various degrees of swelling and on tomato bushy stunt virus treated with the crosslinking agent glutaraldehyde. The detected fluctuations may be related either with cooperative deformational motion in the capsid or with more localized structural changes. Such structural changes may help liberate the RNA at an early stage of viral infection.
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