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  • Title: Effects of phorbol ester on spontaneous transmitter release at frog neuromuscular junction.
    Author: Eusebi F, Molinaro M, Caratsch CG.
    Journal: Pflugers Arch; 1986 Feb; 406(2):181-3. PubMed ID: 2870468.
    Abstract:
    Spontaneous transmitter release was studied at frog neuromuscular junctions exposed to the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of protein kinase C (PrkC). TPA at concentrations between 10(-7) and 10(-6) M induced a dose-dependent increase in miniature end-plate potential frequency. This frequency increase was enhanced by raising [Ca]o, diminished by lowering the temperature of the bath and virtually abolished in Ca2+ -free Ringer. The TPA effect was only poorly reversible after washing. TPA was ineffective in increasing spontaneous release of transmitter at phosphatidylcholine-pretreated neuromuscular junctions. It is suggested that PrkC might play a role in neuromuscular transmission processes.
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