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  • Title: [Effect of N- and M-cholinergic-potentiating and cholinergic-blocking agents on the epileptogenesis of a penicillin focus in the dorsal hippocampus].
    Author: Losev NA, Tkachenko EI.
    Journal: Biull Eksp Biol Med; 1986 Apr; 101(4):436-8. PubMed ID: 2870750.
    Abstract:
    Chronic experiments on rabbits with penicillin epilepsy have shown that intravenous injections of the ACHE inhibitor galanthamine (1 mg/kg), and N-cholinergic-blockers, ganglerone (3 mg/kg) and eterofen (8 mg/kg), decreased or suppressed completely epileptogenesis manifestations. Combination of galanthamine with one of the N-cholinergic-blockers markedly increased their anticonvulsive actions. On the contrary, combination of galanthamine with the M-cholinergic-blocker metamizil (0.5 mg/kg) enhanced epileptogenesis activity. It is postulated that both M- and N-cholinergic mechanisms take part in the genesis of penicillin epilepsy. The use of N-cholinergic-blockers and their combinations with M-cholinomimetics as anticonvulsants seems expedient.
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