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  • Title: Properties of rabbit erythrocytes treated with phospholipase A2 from bee venom.
    Author: Vaysse J, Pilardeau P, Garnier M.
    Journal: Comp Biochem Physiol A Comp Physiol; 1986; 83(4):715-9. PubMed ID: 2870863.
    Abstract:
    In isotonic saline-buffered conditions, phospholipase A2 from bee venom cleaves up to 65% of the phosphatidylcholine of the rabbit RBC membrane without causing significant hemolysis; however, the volume and the osmotic fragility of the treated RBC is modified. The osmotic behaviour of PLA-treated RBC after reincubation in autologous plasma suggests an heterogeneity in the enzymatic attack among the RBC population. In vivo RBC survival is strongly impaired by PLA treatment.
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