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  • Title: Control of rat gastric somatostatin release by gamma-aminobutyric acid (GABA).
    Author: Koop H, Arnold R.
    Journal: Horm Metab Res; 1986 Feb; 18(2):94-7. PubMed ID: 2870970.
    Abstract:
    The influence of gamma-aminobutyric acid (GABA) on gastric somatostatin and gastrin release was studied using an isolated perfused rat stomach preparation. GABA dose-dependently inhibited somatostatin release (maximal inhibition of 44% at 10(-5)M GABA), whereas gastrin secretion was not affected. The GABA agonist muscimol led to a decrease in somatostatin release of similar magnitude. The GABA-induced changes were partially reversed by 10(-5)M atropine. Gastrin secretion was not influenced by either protocol. It is concluded that GABA as a putative neurotransmitter in the enteric nervous system is inhibitory to rat gastric somatostatin release in vitro via cholinergic pathways.
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