These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity.
    Author: Mitchell DE, Clarkson G, Fox DJ, Vipond RA, Scott P, Gibson MI.
    Journal: J Am Chem Soc; 2017 Jul 26; 139(29):9835-9838. PubMed ID: 28715207.
    Abstract:
    Antifreeze proteins are produced by extremophile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just 20 μM. Structure-property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.
    [Abstract] [Full Text] [Related] [New Search]