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  • Title: Effect of discrete brain lesions on hypothalamic and pituitary immunoreactive dynorphin.
    Author: Spampinato S, Stanzani S, Ferri S.
    Journal: Neurosci Lett; 1986 Mar 28; 65(1):109-13. PubMed ID: 2871529.
    Abstract:
    Radiofrequency lesions of the anterior hypothalamic area reduced immunoreactive dynorphin (ir-DYN) in the hypothalamus and in the neurointermediate lobe of the pituitary. Ablation of the medial preoptic area was not associated with any significant modification of ir-DYN in the tissue examined. Destruction of the medial basal hypothalamus in parallel lowered ir-DYN in the hypothalamus and in both pituitary lobes. Neonatal administration of monosodium glutamate had no significant effect on ir-DYN. These findings indicate that changes of ir-DYN in the hypothalamus and pituitary are associated with the destruction of anatomically and functionally distinct neural systems.
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